Professor Nicole Zitzmann | Christ Church, Oxford

Qualifications

MSc, PhD

Role or Position

Biochemistry lecturer

Email address

Nicole.Zitzmann@bioch.ox.ac.uk

Academic Background

Dr Nicole Zitzmann is a Reader in Glycobiology in the Department of Biochemistry, Oxford University; Lecturer in Biochemistry at Christ Church; Senior Research Fellow of Linacre College; and Leader of the Oxford Antiviral Drug Discovery Unit (Dept. of Biochemistry). She held a Dorothy Hodgkin Research Fellowship of the Royal Society from 1999-2003 and a Research Fellowship at Wolfson College, Oxford from 2001-2005. She became group leader of the virus research group in 1999, and of the Proteomics group in 2002.

Undergraduate Teaching

Glycobiology, Virology and Proteomics

Research Interests

Investigation of novel approaches to antiviral therapy, using a multi-disciplinary approach including Glycobiology, Virology, Biophysics and Proteomics. The main targets are Hepatitis C, Hepatitis B, and HIV.

Publications include:

Branza-Nichita, N., D. Durantel, S. Carrouee-Durantel, R.A. Dwek, and N. Zitzmann, Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers. J Virol, 2001. 75(8): p. 3527-36.

Durantel, D., N. Branza-Nichita, S. Carrouee-Durantel, T.D. Butters, R.A. Dwek, and N. Zitzmann, Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus. J Virol, 2001. 75(19): p. 8987-98.

Stumpf, M.P. and N. Zitzmann, RNA replication kinetics, genetic polymorphism and selection in the case of the hepatitis C virus. Proc Biol Sci, 2001. 268(1480): p. 1993-9.

Branza-Nichita, N., C. Lazar, D. Durantel, R.A. Dwek, and N. Zitzmann, Role of disulfide bond formation in the folding and assembly of the envelope glycoproteins of a pestivirus. Biochem Biophys Res Commun, 2002. 296(2): p. 470-6.

Dwek, R.A., T.D. Butters, F.M. Platt, and N. Zitzmann, Targeting glycosylation as a therapeutic approach. Nat Rev Drug Discov, 2002. 1(1): p. 65-75.

Pavlovic, D., D.C. Neville, O. Argaud, B. Blumberg, R.A. Dwek, W.B. Fischer, and N. Zitzmann, The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. Proc Natl Acad Sci U S A, 2003. 100(10): p. 6104-8.

Branza-Nichita, N., C. Lazar, R.A. Dwek, and N. Zitzmann, Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns). Biochem Biophys Res Commun, 2004. 319(2): p. 655-62.

Durantel, D., S. Carrouee-Durantel, N. Branza-Nichita, R.A. Dwek, and N. Zitzmann, Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus. Antimicrob Agents Chemother, 2004. 48(2): p. 497-504.

Garcia, A., S. Prabhakar, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit, and N. Zitzmann, Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry. Proteomics, 2004. 4(3): p. 656-68.

Garcia, A., S. Prabhakar, S. Hughan, T.W. Anderson, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit, and N. Zitzmann, Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood, 2004. 103(6): p. 2088-95.

Durantel, D., N. Branza-Nichita, S. Durantel, R.A. Dweek, and N. Zitzmann, The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein. Adv Exp Med Biol, 2005. 564: p. 5-6.

Garcia, A., S.P. Watson, R.A. Dwek, and N. Zitzmann, Applying proteomics technology to platelet research. Mass Spectrom Rev, 2005. 24(6): p. 918-30.

Pardo, M., A. Garcia, B. Thomas, A. Pineiro, A. Akoulitchev, R.A. Dwek, and N. Zitzmann, Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS. Proteomics, 2005. 5(18): p. 4980-93.

Zitzmann, N., T. Block, A. Methta, P. Rudd, D. Burton, I. Wilson, F. Platt, T. Butters, and R.A. Dwek, Glycosylation: disease targets and therapy. Adv Exp Med Biol, 2005. 564: p. 1-2.

Pardo, M., A. Garcia, B. Thomas, A. Pineiro, A. Akoulitchev, R.A. Dwek, and N. Zitzmann, The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. Int J Cancer, 2006. 119(5):p. 1014-1022

García, A., Y.A. Senis, R. Antrobus, C.E. Hughes, R.A. Dwek, S.P. Watson, and N. Zitzmann, A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics, 2006. 6: p. 5332-5343.

Knight, C. G., N. Zitzmann, S. Prabhakar, R. Antrobus, R. A. Dwek, H. Hebestreit, and P. B. Rainey, Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network. Nature Genetics, 2006. 38(9): p. 1015-1022

Hobbies

Quilting; collecting drawings and paintings

Links

http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=73&Group_ID=58
http://www.bioch.ox.ac.uk/glycob/ogp/index.html


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	College News Admissions Undergraduate Admissions Studying at Christ Church College Prospectus Course Information Living at Christ Church Making an Application Financial Information Open Days Access Initiatives Graduate Admissions Contact Admissions Students & Staff Academic & Research Staff College Officers Subject Areas University Of Oxford	Professor Nicole Zitzmann Qualifications MSc, PhD Role or Position Biochemistry lecturer Email address Nicole.Zitzmann@bioch.ox.ac.uk Academic Background Dr Nicole Zitzmann is a Reader in Glycobiology in the Department of Biochemistry, Oxford University; Lecturer in Biochemistry at Christ Church; Senior Research Fellow of Linacre College; and Leader of the Oxford Antiviral Drug Discovery Unit (Dept. of Biochemistry). She held a Dorothy Hodgkin Research Fellowship of the Royal Society from 1999-2003 and a Research Fellowship at Wolfson College, Oxford from 2001-2005. She became group leader of the virus research group in 1999, and of the Proteomics group in 2002. Undergraduate Teaching Glycobiology, Virology and Proteomics Research Interests Investigation of novel approaches to antiviral therapy, using a multi-disciplinary approach including Glycobiology, Virology, Biophysics and Proteomics. The main targets are Hepatitis C, Hepatitis B, and HIV. Publications include: Branza-Nichita, N., D. Durantel, S. Carrouee-Durantel, R.A. Dwek, and N. Zitzmann, Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers. J Virol, 2001. 75(8): p. 3527-36. Durantel, D., N. Branza-Nichita, S. Carrouee-Durantel, T.D. Butters, R.A. Dwek, and N. Zitzmann, Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus. J Virol, 2001. 75(19): p. 8987-98. Stumpf, M.P. and N. Zitzmann, RNA replication kinetics, genetic polymorphism and selection in the case of the hepatitis C virus. Proc Biol Sci, 2001. 268(1480): p. 1993-9. Branza-Nichita, N., C. Lazar, D. Durantel, R.A. Dwek, and N. Zitzmann, Role of disulfide bond formation in the folding and assembly of the envelope glycoproteins of a pestivirus. Biochem Biophys Res Commun, 2002. 296(2): p. 470-6. Dwek, R.A., T.D. Butters, F.M. Platt, and N. Zitzmann, Targeting glycosylation as a therapeutic approach. Nat Rev Drug Discov, 2002. 1(1): p. 65-75. Pavlovic, D., D.C. Neville, O. Argaud, B. Blumberg, R.A. Dwek, W.B. Fischer, and N. Zitzmann, The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. Proc Natl Acad Sci U S A, 2003. 100(10): p. 6104-8. Branza-Nichita, N., C. Lazar, R.A. Dwek, and N. Zitzmann, Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns). Biochem Biophys Res Commun, 2004. 319(2): p. 655-62. Durantel, D., S. Carrouee-Durantel, N. Branza-Nichita, R.A. Dwek, and N. Zitzmann, Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus. Antimicrob Agents Chemother, 2004. 48(2): p. 497-504. Garcia, A., S. Prabhakar, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit, and N. Zitzmann, Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry. Proteomics, 2004. 4(3): p. 656-68. Garcia, A., S. Prabhakar, S. Hughan, T.W. Anderson, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit, and N. Zitzmann, Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood, 2004. 103(6): p. 2088-95. Durantel, D., N. Branza-Nichita, S. Durantel, R.A. Dweek, and N. Zitzmann, The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein. Adv Exp Med Biol, 2005. 564: p. 5-6. Garcia, A., S.P. Watson, R.A. Dwek, and N. Zitzmann, Applying proteomics technology to platelet research. Mass Spectrom Rev, 2005. 24(6): p. 918-30. Pardo, M., A. Garcia, B. Thomas, A. Pineiro, A. Akoulitchev, R.A. Dwek, and N. Zitzmann, Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS. Proteomics, 2005. 5(18): p. 4980-93. Zitzmann, N., T. Block, A. Methta, P. Rudd, D. Burton, I. Wilson, F. Platt, T. Butters, and R.A. Dwek, Glycosylation: disease targets and therapy. Adv Exp Med Biol, 2005. 564: p. 1-2. Pardo, M., A. Garcia, B. Thomas, A. Pineiro, A. Akoulitchev, R.A. Dwek, and N. Zitzmann, The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. Int J Cancer, 2006. 119(5):p. 1014-1022 García, A., Y.A. Senis, R. Antrobus, C.E. Hughes, R.A. Dwek, S.P. Watson, and N. Zitzmann, A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics, 2006. 6: p. 5332-5343. Knight, C. G., N. Zitzmann, S. Prabhakar, R. Antrobus, R. A. Dwek, H. Hebestreit, and P. B. Rainey, Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network. Nature Genetics, 2006. 38(9): p. 1015-1022 Hobbies Quilting; collecting drawings and paintings Links http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=73&Group_ID=58 http://www.bioch.ox.ac.uk/glycob/ogp/index.html Updated: Friday 25th November 2011 10:02 Printable Version