Dr Alvina Lai

Biological Sciences
Lecturer in Biological Sciences

Qualifications

PhD Plant Molecular Biology (Massey University, New Zealand).

Academic Background

Research Fellow in Zoology

Undergraduate Teaching

Tutorials for Cells and Genes (Merton College, 2017) and Medical Genetics (Keble College, 2016).

Research Interests

Genomics

Publications

Lai AG, Kosaka N, Abnave P, Sahu S, Aboobaker AA. The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells. Dev Biol. 2017. DOI

Lai AG, Aboobaker AA. Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species. BMC Genomics. 2017. 18;18(1):389. DOI

Lai AG, Pouchkina-Stantcheva N, Di Donfrancesco A, Kildisiute G, Sahu S, Aboobaker AA. The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa. BMC Evol Biol. 2017. 17(1):107. DOI

Kao D, Mihaylova Y, Hughes S, Lai A, Aboobaker AA. Epigenetic analyses of the planarian genome reveals conservation of bivalent promoters in animal stem cells. BioRxiv 2017. DOI

Mihaylova Y, Kao D Hughes S, Lai A, Jaber-Hijazi F, Kosaka N, Abnave P, Aboobaker AA. MLL3/4 Prevents Stem Cell Hyperplasia And Controls Differentiation Programs In A Planarian Cancer Stem Cell Model. bioRxiv 2017. 126540; DOI 

Kao D, Lai AG, Stamataki E, Rosic S, Konstantinides N, Jarvis E, Di Donfrancesco A, Pouchkina-Stancheva N, Semon M, Grillo M, Bruce H, Kumar S, Siwanowicz I, Le A, Lemire A, Eisen MB, Extavour C, Browne WE, Wolff C, Averof M, Patel NH, Sarkies P, Pavlopoulos A, Aboobaker A. The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion. Elife. 2016. 16;5. pii: e20062. DOI 

Schippers JH, Lai AG, Mueller-Roeber B, Dijkwel PP. Could ROS signals drive tissue-specific clocks? Transcription. 2013. 4(5):206-8.

Lai AG, Doherty CJ, Mueller-Roeber B, Kay SA, Schippers JH, Dijkwel PP. CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses. Proc Natl Acad Sci U S A. 2012. 109(42):17129-34. DOI 

Lai AG, Denton-Giles M, Mueller-Roeber B, Schippers JH, Dijkwel PP. Positional information resolves structural variations and uncovers an evolutionarily divergent genetic locus in accessions of Arabidopsis thaliana. Genome Biol Evol. 2011. 3:627-40. DOI