Dr Sam Thompson

Chemistry
Lecturer in Chemical Biology and Medicinal Chemistry

Qualifications

MChem (Oxford 2000-4), PhD (Cambridge 2004-8), DPhil (Oxford 2013, incorp.)

Academic Background

Exeter College, Oxford; MChem (2004)
St. Edmund’s College, Cambridge; PhD (2008)
Junior Research Fellow in Chemistry, Pembroke College and Lady Margaret Hall, Oxford, (2009 – 2016)
Senior Research Fellow with Professor Andrew D. Hamilton FRS, Dept. Chemistry, Oxford (2010 – 2016)
Lecturer in Organic Chemistry, Christ Church, Oxford (2013 – current)
Lecturer in Chemical Biology and Medicinal Chemistry, University of Southampton (2016 – current)

Undergraduate Teaching

Organic Chemistry

Research Interests

Chemistry for biology and medicine.

Publications 

28.  Nathalie Busschaert, Sam Thompson, Andrew D. Hamilton – ‘An α-helical peptidomimetic scaffold for dynamic combinatorial library formation’. Chem. Commun. 2017, 53, front cover: p. 269 [DOI], article: pp. 313-316 [DOI].

27.  Hayden Peacock, Jinghui Luo, Tohru Yamashita, James Luccarelli, Sam Thompson, Andrew D. Hamilton – ‘Non-Covalent S×××O Interactions Control Conformation in a Scaffold that Disrupts Islet Amyloid Polypeptide Fibrillation’. Chem Sci., 2016, 7, 6435-6439 [DOI].

26.  Peter C. Knipe, Sam Thompson, Andrew D. Hamilton – ‘Acid-Mediated Topological Control in a Functionalized Foldamer’ (Hot paper). Chem. Commun., 2016, 52, article: pp. 6521-6524 [DOI], back cover: p. 6627 [DOI].

25.  Tohru Yamashita, Peter C. Knipe, Nathalie Busschaert, Sam Thompson, Andrew D. Hamilton – ‘A Modular Synthesis of Conformationally Preorganised Extended b-Strand Peptidomimetics’ (Hot paper). Chem. Eur. J., 2015, 21, front cover: p. 14,653 [DOI], cover profile: p. 14,657 [DOI], article: pp. 14,699-14,702 [DOI].

24.  Jonathan E. Ross, Peter C. Knipe, Sam Thompson, Andrew D. Hamilton – ‘Hybrid diphenylalkyne-dipeptide oligomers induce multi‑strand b-sheet formation’. Chem. Eur. J., 2015, 21, pp. 13,518-13,521 [DOI].

23.  Oleg V. Kulikov, Sunil Kumar, Mazin Magzoub, Peter C. Knipe, Ishu Saraogi, Sam Thompson, Andrew D. Miranker – ‘Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation’. Tetrahedron Lett., Invited contribution for the Special Issue in memory of Professor Harry Wasserman, 2015, 56, pp. 3670-3673 [DOI].

22.  Peter C. Knipe, Sam Thompson, Andrew D. Hamilton – ‘Ion-Mediated Conformational Switches’. Chem Sci., Invited perspective, 2015, 6, pp. 1630-1639 [DOI].

21.  Elizabeth A. German, Jonathan E. Ross, Peter C. Knipe, Michaela F. Don, Sam Thompson, Andrew D. Hamilton – ‘β-Strand mimetic foldamers rigidified through dipolar repulsion’. Angew. Chem. Int. Ed. 2015, 54, pp. 2649-2652 [DOI].

20.  Peter C. Knipe, Ian M. Jones, Sam Thompson, Andrew D. Hamilton – ‘Remote conformational control of a molecular switch via methylation and deprotonation’. Org. Biomol. Chem. 2014, 12, pp. 9384-9388 [DOI].

19.  Peter C. Knipe, Hannah Lingard, Ian M. Jones, Sam Thompson, Andrew D. Hamilton – ‘A Lewis acid-mediated conformational switch’. Org. Biomol. Chem. 2014, 12, pp. 7937-7941 [DOI].

18.  Ian M. Jones, Peter C. Knipe, Thoe Michaelos, Sam Thompson, Andrew D. Hamilton – ‘Redox-dependent conformational switching of diphenylacetylenes’. Molecules, Invited contribution for the Special Issue: Intramolecular Hydrogen Bonding, 2014, 19, pp. 11,316-11,332 [DOI].

17.  Hannah Lingard, Jeongmin T. Han, Amber L. Thompson, Richard T.W. Scott, Sam Thompson, Andrew D. Hamilton – ‘Diphenylacetylene-linked peptide strands induce bi-directional b-sheet formation’ (Hot paper). Angew. Chem. Int. Ed. 2014, 53, front cover: p. 3521 [DOI], article: pp. 3650-3653 [DOI].

16.  Madura K.P. Jayatunga, Sam Thompson, Andrew D. Hamilton – ‘α-Helix mimetics: Outwards and Upwards’. Bioorg. Med. Chem. Lett., Invited review, 2014, 24, pp. 717-724 [DOI].

15.  Laura Nevola, Johanna M. Rodriguez, Sam Thompson, Andrew D. Hamilton – ‘Super-secondary structure peptidomimetics: design and synthesis of an a-a hairpin motif analogue’. Supramol. Chem., Invited contribution for the Special Issue honouring Professor Rocco Ungaro, 2013, 25, pp. 586-590 [DOI].

14.  Sam Thompson, Andrew J. Wilson, Alan R. Battersby – ‘In celebration of the 60th birthday of Professor Andrew D. Hamilton FRS’. Org. Biomol. Chem. 2013, 11, pp. 6236-6241 [DOI].

13.  Madura K.P. Jayatunga, Sam Thompson, Tawnya C. McKee, Mun Chiang Chan, Kelie M. Reece, Adam P. Hardy, Rok Sekirnik, Peter T. Seden, Kristina M. Cook, James B. McMahon, William D. Figg, Christopher J. Schofield, Andrew D. Hamilton – ‘Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(ii)’. Eur. J. Med. Chem., Invited contribution for the Special Issue: Protein-Protein Interactions: Mechanisms, Inhibitors and Stabilizers, 2015, 94, pp. 509-516 [DOI].

12.  James E. Egleton, Cyrille C. Thinnes, Peter T. Seden, Nicola Laurieri, Sui Po Lee, Kate S. Hadavizadeh, Angelina R. Measures, Alan M. Jones, Sam Thompson, Amy L. Varney, Julien Dairou, Graham M. Wynne, Ali Ryan, Edith Sim, Angela J. Russell – ‘Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1’. Bioorg. Med. Chem. 2014, 22, pp. 3030-3054 [DOI].

11.  Nicola Laurieri, James E. Egleton, Amy Varney, Cyrille C. Thinnes, Camilo E. Quevedo, Peter T. Seden, Sam Thompson, Fernando Rodrigues-Lima, Julien Dairou, Angela J. Russell, Edith Sim – ‘A Novel Color Change Mechanism for Breast Cancer Biomarker Detection: Naphthoquinones as Specific Ligands of Human Arylamine N-Acetyltransferase 1’. PLoS ONE 2013, 8, e70600 [DOI].

10.  Oleg V. Kulikov, Sam Thompson, Hai Xu, Christopher D. Incarvito, Richard T.W. Scott, Ishu Saraogi, Laura Nevola, Andrew D. Hamilton – ‘Design and synthesis of oligoamide-based double a-helix mimetics’. Eur. J. Org. Chem., Invited contribution for the special issue: Foldamers, 2013, front cover: p. 3407 [DOI] & article: pp. 3433-3445 [DOI].

9.     Philip C. Simister, James Luccarelli, Sam Thompson, Daniel H. Appella, Stephan M. Feller, Andrew D. Hamilton – ‘Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen’. Bioorg. Med. Chem., Invited contribution for the Special Issue: Inhibition and Stabilization of Protein-Protein Interactions, 2013, 21, pp. 4027-4033 [DOI].

8.     Charlotte L. Sutherell, Sam Thompson, Richard T.W. Scott, Andrew D. Hamilton – ‘Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics’. Chem. Commun. 2012, 48, pp. 9834-9836 [DOI].

7.     Sam Thompson, Andrew D. Hamilton – ‘Amphiphilic a-helix mimetics based on a benzoylurea scaffold’. Org. Biomol. Chem., Invited contribution for the Special Issue: Organic & Biomolecular Chemistry 10th Anniversary, 2012, 10, pp. 5780-5782 [DOI].

6.     Sam Thompson, Ramakrishnan Vallinayagam, Marc J. Adler, Richard T.W. Scott, Andrew D. Hamilton – ‘Double-Sided a‑Helix Mimetics’. Tetrahedron, Invited contribution for the Special Issue: Chemistry of Foldamers, 2012, 68, pp. 4501-4505 [DOI].

5.     Sam Thompson, Anthony G. Coyne, Peter C. Knipe, Martin D. Smith – ‘Asymmetric Electrocyclic Reactions’. Chem. Soc. Rev., Invited review, 2011, 40, pp. 4217-4231 [DOI].

4.     Eleanor E. Maciver, Sam Thompson, Martin D. Smith – ‘Catalytic Asymmetric 6p Electrocyclization: Enantioselective Synthesis of Functionalized Indolines’. Angew. Chem. Int. Ed. 2009, 48, pp. 9979-9982 [DOI].

3.     Goncalo J.L. Bernardes, Elizabeth J. Grayson, Sam Thompson, Justin M. Chalker, James C. Errey, Farid El Oualid, Timothy D.W. Claridge, Benjamin G. Davis – ‘From disulfide- to thioether-linked glycoproteins’. Angew. Chem. Int. Ed. 2008, 47, pp. 2244-2247 [DOI].

Book Chapters

2.     Peter C. Knipe, Sam Thompson, Andrew D. Hamilton – ‘Molecular Recognition in Biomimetic Receptors’. In ‘Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field’; Editor, Ed.; Wiley‑VCH, Weinheim, 2016, In press.

1.     James Luccarelli, Sam Thompson, Andrew D. Hamilton – ‘SH3 domains as drug targets’. In ‘Methods and Principles in Medicinal Chemistry: Protein-Protein Interactions in Drug Discovery’; Alexander Domling, Ed.; Wiley-VCH, Weinheim, 2013, pp. 101-128 [DOI].