Dr Alvina Lai

Biological Sciences
Lecturer in Biological Sciences

Qualifications

PhD Plant Molecular Biology (Massey University, New Zealand).

Academic Background

Research Fellow in Zoology

Undergraduate Teaching

Tutorials for Cells and Genes (Merton College, 2017) and Medical Genetics (Keble College, 2016).

Research Interests

Genomics

Publications

Chang WH, Lai AG. Comparative genomic analysis of crustacean hyperglycemic hormone (CHH) neuropeptide genes across diverse crustacean species. F1000Research 2018; 7.

Mihaylova Y, Abnave P, Kao D, et al. Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells. Nat Commun 2018; 9: 3633.

Zhuang X, Lai AG, McKeating JA, Rowe I, Balfe P. Daytime variation in hepatitis C virus replication kinetics following liver transplant. Wellcome open Res 2018; 3: 96.

Dattani A, Kao D, Mihaylova Y, et al. Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent  histone modifications in animal stem cells. Genome Res 2018; published online Aug. DOI:10.1101/gr.239848.118.

Chang WH, Lai AG. Mixed evolutionary origins of endogenous biomass-depolymerizing enzymes in animals. BMC Genomics 2018; 19: 483.

Chang WH, Lai AG. A TALE of shrimps: Genome-wide survey of homeobox genes in 120 species from diverse crustacean taxa. F1000Research 2018; 7: 71.

Chang WH, Lai AG. Genome-wide analyses of the bHLH superfamily in crustaceans: reappraisal of higher-order groupings and evidence for lineage-specific duplications. R Soc open Sci 2018; 5: 172433.

Lai AG, Aboobaker AA. EvoRegen in animals: Time to uncover deep conservation or convergence of adult stem cell evolution and regenerative processes. Dev Biol 2018; 433: 118–31.

Zhuang X, Rambhatla SB, Lai AG, McKeating JA. Interplay between circadian clock and viral infection. J Mol Med (Berl) 2017; 95: 1283–9.

Lai AG, Kosaka N, Abnave P, Sahu S, Aboobaker AA. The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells. Dev Biol 2018; 433: 218–26.

Lai AG, Pouchkina-Stantcheva N, Di Donfrancesco A, Kildisiute G, Sahu S, Aboobaker AA. The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa. BMC Evol Biol 2017; 17: 107.

Kao D, Lai AG, Stamataki E, et al. The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion. Elife 2016; 5. DOI:10.7554/eLife.20062.

Lai AG, Aboobaker AA. Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species. BMC Genomics 2017; 18: 389.

Lai AG, Doherty CJ, Mueller-Roeber B, Kay SA, Schippers JHM, Dijkwel PP. CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses. Proc Natl Acad Sci 2012; 109: 17129–34.

Lai AG, Denton-Giles M, Mueller-Roeber B, Schippers JHM, Dijkwel PP. Positional information resolves structural variations and uncovers an evolutionarily divergent genetic locus in accessions of Arabidopsis thaliana. Genome Biol Evol 2011; 3: 627–40.

Schippers JHM, Lai AG, Mueller-Roeber B, Dijkwel PP. Could ROS signals drive tissue-specific clocks? Transcription 2013; 4: 206–8.