MSc, MA (Cambridge); DPhil (Oxford)

Academic background

I was educated at Robinson College, Cambridge (BA MSc, 2009–13) and Keble College, Oxford (DPhil, 2013–17), after which I was a Senior Demonstrator and Course Developer for the University of Oxford Department of Chemistry (2017–18). Since 2018 I have been a Departmental Lecturer in Practical Chemistry at the Department of Chemistry, and since 2019 I have been a Lecturer in Physical Chemistry at Christ Church. 

Undergraduate teaching

I teach Physical and Biophysical Chemistry

Research interests

My research focuses on enzyme structure and mechanisms, and on chemical education and teaching practice.

Featured publications

Cahill, S. T., Tyrrell, J. M., Hopkins Navratilova, I., Calvopiña, K., Robinson, S. W., Lohans, C. T., McDonough, M. A., Cain, R., Fishwick, C. W. G., Avison, M. B., Walsh, T. R., Schofield, C. J., Brem, J. Studies on the Inhibition of AmpC and Other β-Lactamases by Cyclic Boronates. Biochim Biophys Acta Gen Subj. 2019

Zhang, D., Markoulides, M. S., Stepanovs, D., Rydzik, A. M., El-Hussein, A., Bon, C., Kamps, J. J. A. G., Umland, K. D., Collins, P. M., Cahill, S. T., Wang, D. Y., von Delft, F., Brem, J., McDonough, M. A. & Schofield, C. J. Structure Activity Relationship Studies on Rhodanines and Derived Enethiol Inhibitors of Metallo-β-Lactamases. Bioorg. Med. Chem. 2018

Cain, R., Brem, J., Zollman, D., McDonough, M. A., Johnson, R. M., Spencer, J., Makena, A. Abboud, M. I., Cahill, S., Lee, S.Y., McHugh, P.J., Schofield & C. J., Fishwick C. W. G. In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors. J. Med. Chem. 2018

Lohans, C. T., Wang, D. Y., Jorgensen, C., Cahill, S. T., Clifton, I. J., McDonough, M. A., Oswin, H. P., Spencer, J., Domene, C., Claridge, T. D. W., Brem, J. & Schofield, C. J. 13C-Carbamylation as a Mechanistic Probe for the Inhibition of Class D β-Lactamases by Avibactam and Halide Ions. Org. Biomol. Chem. 2017

Cahill, S.T., Cain, R., Wang, D. Y., Lohans, C. T., Wareham, D. W., Oswin, H. P., Mohammed, J., Spencer, J., Fishwick, C. W. G., McDonough, M. A., Schofield, C. J. & Brem, J. Cyclic Boronates Inhibit All Classes of β-Lactamase Antimicrob. Agents Chemother. 2017, 61, e02260-16

Brem, J., Cain, R., Cahill, S., McDonough, M. A., Clifton, I. J., Jiménez-Castellanos, J-C., Avison, M. B., Spencer, J., Fishwick, C. W. G. & Schofield, C. J. Structural Basis of Metallo-β-Lactamase, Serine-β-Lactamase and Penicillin-Binding Protein Inhibition by Cyclic Boronates. Nat. Commun. 2016, 7, 12406

Cahill, S.T., Tarhonskaya, H., Rydzik, A. M., Flashman, E., McDonough, M. A., Schofield, C. J. & Brem, J. Use of Ferrous Iron by Metallo-β-Lactamases. J. Inorg. Biochem. 2016, 163, 185-193