Dr Sam Thompson

Associate Professor in Organic Chemistry


Senior Fellow (Higher Education Academy 2018)
DPhil (Oxford 2013, incorp.)
PhD (Cambridge 2004-8)
MChem (Oxford 2000-4)

Academic Background

Associate Professor in Chemical Biology and Medicinal Chemistry, University of Southampton (2023 – current)
Lecturer in Organic Chemistry, Christ Church, Oxford (2013 – current)
Lecturer in Chemical Biology and Medicinal Chemistry, University of Southampton (2016 – 2023)
Senior Research Fellow with Professor Andrew D. Hamilton FRS, Dept. Chemistry, Oxford (2010 – 2016)
Junior Research Fellow in Chemistry, Pembroke College and Lady Margaret Hall, Oxford, (2009 – 2016)
St. Edmund’s College, Cambridge; PhD (2008)
Exeter College, Oxford; MChem (2004)

Undergraduate Teaching

Organic Chemistry

Research Interests

Chemistry for biology and medicine.

Selected Publications 

Clementine E. Bavinton, Rebecca Sternke-Hoffmann, Tohru Yamashita, Peter C. Knipe, Andrew D. Hamilton, Jinghui Luo, Sam Thompson – ‘Rationally designed helical peptidomimetics disrupt alpha-synuclein fibrillation’. Chem. Commun., 2022, 58, pp. 5132-5135.
Hayden Peacock, Jinghui Luo, Tohru Yamashita, James Luccarelli, Sam Thompson, Andrew D. Hamilton – ‘Non-Covalent S-O Interactions Control Conformation in a Scaffold that Disrupts Islet Amyloid Polypeptide Fibrillation’. Chem Sci. 2016, 7, pp. 6435-6439.
Peter C. Knipe, Sam Thompson, Andrew D. Hamilton – ‘Ion-Mediated Conformational Switches’. Chem Sci., Invited perspective, 2015, 6, pp. 1630-1639.
Elizabeth A. German, Jonathan E. Ross, Peter C. Knipe, Michaela F. Don, Sam Thompson, Andrew D. Hamilton – ‘β-Strand mimetic foldamers rigidified through dipolar repulsion’. Angew. Chem. Int. Ed. 2015, 54, pp. 2649-2652.
Hannah Lingard, Jeongmin T. Han, Amber L. Thompson, Richard T.W. Scott, Sam Thompson, Andrew D. Hamilton – ‘Diphenylacetylene-linked peptide strands induce bi-directional b-sheet formation’ (Hot paper). Angew. Chem. Int. Ed. 2014, 53, front cover: p. 3521, article: pp. 3650-3653.
Charlotte L. Sutherell, Sam Thompson, Richard T.W. Scott, Andrew D. Hamilton – ‘Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics’. Chem. Commun. 2012, 48, pp. 9834-9836.
Sam Thompson, Anthony G. Coyne, Peter C. Knipe, Martin D. Smith – ‘Asymmetric Electrocyclic Reactions’. Chem. Soc. Rev., Invited review, 2011, 40, pp. 4217-4231.
Eleanor E. Maciver, Sam Thompson, Martin D. Smith – ‘Catalytic Asymmetric 6pi Electrocyclization: Enantioselective Synthesis of Functionalized Indolines’. Angew. Chem. Int. Ed. 2009, 48, pp. 9979-9982.
Goncalo J.L. Bernardes, Elizabeth J. Grayson, Sam Thompson, Justin M. Chalker, James C. Errey, Farid El Oualid, Timothy D.W. Claridge, Benjamin G. Davis – ‘From disulfide- to thioether-linked glycoproteins’. Angew. Chem. Int. Ed. 2008, 47, pp. 2244-2247.